I've never done such a thing, so keep that in mind, but it strikes me that you might be more concerned about ending each episode with a cliffhanger than you would with novel chapters. (Of course, this depends on the kind of story being told--and, of course, some novelists might think it wise to end chapters with cliffhangers.)
After all, if someone buys or even sits down to read a novel, that person is invested to try to get through the whole thing. It's far easier to not
tune in next week or next month with an audio drama. You have to motivate them to continue with the series.
My hunch is that you also might want to think a bit about having subplots resolve with each installment, so that along with the cliffhanger, there's still some sense of resolve.
As I say, this is off the top of my head, but I'm really interested to see how this conversation develops. I have no immediate plans to do what you're planning, but it's cool stuff to think about.